Abstract
Sulfated tungstate catalyzed hydration of alkynes
Highlights
The catalytic hydration of alkynes, leading to the formation of aldehydes and ketones is of considerable interest because of availability of alkynyl substrates and the fundamental importance of aldehydes and ketones for bulk and fine chemical industries
Alkyne hydration has been employed in the synthesis of active pharmaceutical ingredients, such as azaperone, benperidol, droperidol and fexofenadine
Colorless liquid; Rf 0.47 (n-hexane/EtOAc, 90:10); IR: 1726, 1741 cm-1; 1H NMR (300 MHz; CDCl3; Me4Si): δH 7.97-8.00 (m, 2H), 7.45-7.50 (m, 1H), 7.32-7.36 (m, 2H), 4.77 (s, 2H), 2.10 (s, 3H)
Summary
The catalytic hydration of alkynes, leading to the formation of aldehydes and ketones is of considerable interest because of availability of alkynyl substrates and the fundamental importance of aldehydes and ketones for bulk and fine chemical industries.
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