Sulfated polyborate: A mild, efficient catalyst for synthesis of N-tert-butyl/N-trityl protected amides via Ritter reaction

Abstract

Rapid, efficient and inexpensive method for synthesis of N-tert-butyl/N-trityl protected amides via Ritter reaction of nitriles with tertiary alcohols in the presence of a sulfated polyborate catalyst under solvent-free conditions is described. The catalyst has the advantage of Lewis as well as Bronsted acidity and recyclability without significant loss in catalytic activity along with easy work-up, short reaction time and good to excellent yields.