Abstract
Co-administration of two or more drugs has recently become a viable option for treating a variety of diseases, including rheumatoid arthritis (RA). A simple method was used to encapsulate drugs with different solubilities in the same matrix. The internal space of halloysite nano tubes was increased by acid treatment prior to drug loading. Nimesulide (NIMS, an NSAID) and sulfasalazine (SLZ, a DMARD) were loaded into the halloysite lumen either individually or in combination. The halloysite-drug conjugates were then incorporated with poly [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (PSBMA) matrix during free radical crosslinking polymerization. Different kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas) were studied to fit single and combined drug release kinetics. When compared to its sole drug formulation, the combined drug release kinetics demonstrated different release mechanisms. Both drugs were released more slowly as pH decreased, owing to their decreasing solubility. Cell culture tests revealed that the composite hydrogel was not cytotoxic.
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