Abstract
Summary A simple laboratory procedure for demonstrating relative sulfapyridine resistance of strains of pneumococci has been presented. Its limitations have been cited. The test was applied to cultures from two patients who did not respond to sulfapyridine. These showed marked resistance to sulfapyridine as compared with similar cultures from patients not receiving chemotherapy and with cultures obtained before administration of the drug in the same patient. It was shown in vitro that sulfanilamide, sulfapyridine, and sulfathiazole differed in the potency in which they prevented the colonial growth of pneumococci, sulfanilamide being the weakest and sulfathiazole the strongest.
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