Abstract
To demonstrate the irreversible poisoning action of the acetone cyanohydrin (AC) in malignant cells. Thirty male Swiss mice were inoculated with 1 x 10³ Ehrlich tumor (ET) cells. The mice were divided into three groups (n=10): CG (saline); ACG1 (1.864 mg/Kg of AC) and ACG2 (2.796 mg/Kg of AC), treated every 48 hours from day 3 until day 13. On day 15 the mice were euthanized and the number of viable cells in ascites was determined. In the meantime, ET cells were incubated with AC (0.5, 1.0, 2.0 μg/mL). Cell viability and percentage of growth inhibition (PGI) were checked after one, two, three, four, 18 and 24 hours. There was reduction in volume and number of viable cells in ACG1 and ACG2 compared to CG. In ACG1 one of the animals did not present ascites. In ACG2 two mice did not present ascites and in CG none of the mice present ascites. The action of AC was dose and time dependent and there was no significant difference among the three doses. The acetone cyanohydrin promoted reduction of the tumor and also prevented tumor development in 20% of the treated animals.
Highlights
Cancer study is being conducted by numerous scientists around the world and their findings in oncology make it one of the greatest and most rapidly evolving areas in modern medicine, causing great technological advances and a growing understanding of what cancer is. cancer has many heterogeneous characteristics, malignant tumors have developed a feature which causes them to grow beyond the imposed limits of the regular cells
Toohey suggests that the uncontrolled proliferation of neoplastic cells is a result of the deficiency of sulfane sulfur and hyperactivity of these enzimes, which would be inhibited in regular cells by that active form of sulfur[2,3]
The CG received 0.4 ml of saline intraperitoneally; ACG1 received 0.4 ml of acetone cyanohydrin 1.864 mg/kg intraperitoneally and, the ACG2 received 0.4 ml of acetone cyanohydrin 2.796 mg/kg intraperitoneally. 48 hours after the last treatment, the animals were euthanized by an overdose of anesthetic to measure the antitumor activity of acetone cyanohydrin
Summary
Cancer has many heterogeneous characteristics, malignant tumors have developed a feature which causes them to grow beyond the imposed limits of the regular cells. The clonal expansion of a transformed cell depends on its uncontrolled proliferative capacity and an increasing inability to die by apoptosis. Even though there is a great variety of cancer types, evidence has shown that resistance to apoptosis is one of the most remarking characteristics of the majority of malignant tumors[1]. The biosynthesis and transport of compounds from the sulfane sulfur set do not occur in these cells. Toohey suggests that the uncontrolled proliferation of neoplastic cells is a result of the deficiency of sulfane sulfur and hyperactivity of these enzimes, which would be inhibited in regular cells by that active form of sulfur[2,3]
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