Abstract
Chickens of 4 weeks of age were divided into one control group and three medicated groups fed with the diet containing 25, 50 and 100ppm sulfamonomethoxine (SMM). After 3 weeks, the diet spiked with SMM was withdrawn and all chickens were fed with SMM-free diet. During the administration and withdrawal periods, 3 hends of each group were killed to collect samples of blood, heart, liver, spleen, gizzard, thigh muscle, breast muscle, and fat.The concentrations of SMM in tissues were determined by high performance liquid chromatography. The concentration in each tissue increased in proportion to the spiked SMM level. The concentrations in blood, heart and liver were higher than those of the other tissues.After the withdrawal of diet spiked with SMM, the concentration of SMM in each tissue decreased rapidly, and the residual SMM was below the detection limit after 2 days.
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