Sulfamic acid-functionalized magnetic Fe 3O 4 nanoparticles as an efficient and reusable catalyst for one-pot synthesis of α-amino nitriles in water

Abstract

Grafting of chlorosulfuric acid on the amino-functionalized Fe 3O 4 nanoparticles afforded sulfamic acid-functionalized magnetic Fe 3O 4 nanoparticles (SA-MNPs) as a novel organic–inorganic hybrid heterogeneous catalyst, which was characterized by XRD, FT-IR, TGA, TEM, and elemental analysis. The catalytic activity of SA-MNPs was probed through one-pot synthesis of α-amino nitriles via three-component couplings of aldehydes (or ketones), amines and trimethylsilyl cyanide in water, at room temperature. The heterogeneous catalyst could be recovered easily and reused many times without significant loss of its catalytic activity.