Abstract
ObjectivesThe authors wanted to determine if the current local practice (initial prescription and monitoring) in pediatrics allowed reaching vancomycin therapeutic concentrations. Patients and methodsThirty patients that had received vancomycin for at least five days with at least one evaluation of serum concentration, at the Sainte-Justine university hospital center, were retrospectively studied. Vancomycin trough and peak levels were analyzed. ResultsThe values of vancomycin serum concentration were within therapeutic ranges (local standards of 5 to 10mg/L for trough level and 20 to 40mg/L for peak level) in 60% and 33% of cases at the fifth day of treatment for trough and peak levels, respectively. ConclusionThe current practice does not allow reaching vancomycin serum concentrations in the target range. Using a wider range for the trough values could be considered.
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