Abstract
The placenta in the pig is membranous throughout gestation and is suitable for investigation as a membrane system. Permeability to antipyrine, tritiated water, 14C urea, and 24Na was determined. These solutes were selected in order to facilitate comparison with data for sheep. The solutes can be arranged in the following order of decreasing permeability for the epitheliochorial placental layer: Tritiated water > antipyrine 14 C urea 24Na. The transfer in vitro of 24Na and 14C urea across the pig placenta appears to reflect the findings in vivo across the sheep placenta. In contrast with permeability measurements in vitro in sheep, data on pig placental permeability refer to representative portions of the exchanging area in vivo.
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