Abstract
BackgroundHigh concentrations of Co, Ni, and Cr in the blood serum of dental technicians are strongly associated with free radical formation. It has highly reactive properties that can cause further oxidation of molecule in the vicinity.PurposeThis study intended to investigate whether the Dental Technician occupational exposure of Co, Ni and Cr, could contribute to the high incidence of cancer.MethodsThis was a cross-sectional study to dental technicians, performed after acccepting ethical clearance. Blood was sampled in 3 examinations for Co, Ni, Cr using Atomic Absorbance Spectrophotometry (AAS), MDA was examined with TBARS test, also 8 OHdG and wildtype p53 proteins determined by ELISA method.ResultsComparative statistical analysis, showing a significant difference (p < 0.05) between levels of Co, Ni, and Cr in exposed groups to the control group. But, not all variables was proven to be positively correlated, only with Cr, and Co, and negatively correlated with wild-type p53.ConclusionMDA,8-OHdG and wildtype p53 can be used as genotoxic biomarkers in the metal exposed group, since they can accurately reflect the degree of Oxidative damage.
Highlights
The alloys Cobalt-chromium (Co-Cr) and NickelChromium (Ni-Cr) are used extensively in dental medicine for removable partial dentures, porcelain-fused-tometal crowns, and metal frames and because they are, as compared to gold, bio-compatible, have a remarkable strength, corrosive resistant, and relatively less costly [1]
The objective of this study was to review the suitability of MDA, 8-OHdG and p53 as Genotoxic Biomarkers, of Co, Ni and Cr dental technicians exposed in the workplace in contributing to the high incidence of cancer from metal exposure in the workplace
Sample of the study The participants of this study were 40 individuals working as the dental technicians who worked on the metal prosthesis for at least 3 years in Dental Laboratory Surabaya, Indonesia
Summary
The alloys Cobalt-chromium (Co-Cr) and NickelChromium (Ni-Cr) are used extensively in dental medicine for removable partial dentures, porcelain-fused-tometal crowns, and metal frames and because they are, as compared to gold, bio-compatible, have a remarkable strength, corrosive resistant, and relatively less costly [1]. The study, conducted by Hariyani et al, proved the impact of metal exposure significantly, ie the concentration of metal in the blood of dental technicians is higher than the control through research entitled, the effect of controlling the work environment on the levels of Co, Ni and Cr in the blood of the dental technicians [3]. The high concentration of Co, Ni and Cr is strongly associated with the formation of free radicals. High concentrations of Co, Ni, and Cr in the blood serum of dental technicians are strongly associated with free radical formation. Purpose: This study intended to investigate whether the Dental Technician occupational exposure of Co, Ni and Cr, could contribute to the high incidence of cancer
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