Abstract

The study aim was to establish and quantify suicide risk following acute admissions for all major physical illnesses, for confirmatory purposes, from two independent information sources from different countries. Record linkage of inpatient and death certificate data for 11 004 389 acute admissions for physical illnesses in England and 713 496 in Wales. The main outcome measure was standardised mortality ratios (SMRs) for suicide at 1 year following discharge from hospital. There were 1781 suicides within 1 year of discharge in England (SMR = 1.7; 95% = 1.6-1.8) and 131 in Wales (SMR = 2.0; 1.7-2.3). Of 48 major physical illnesses that were associated with at least eight suicides in either country, there was high consistent suicide mortality (significant SMR >3) in both countries for constipation (SMR = 4.1 in England, 7.5 in Wales), gastritis (4.4 and 4.9) and upper gastrointestinal bleeding (3.4 and 4.5). There was high suicide mortality in one country for alcoholic liver disease, other liver disease and chronic pancreatitis; for epilepsy and Parkinson's disease; for diabetes, hypoglycaemia and hypo-osmolality & hyponatraemia; and for pneumonia, back pain and urinary tract infections. There is little or no increased suicide mortality following acute admissions for most physical illnesses. Much of the increased suicide mortality relates to gastrointestinal disorders that are often alcohol related or specific chronic conditions, which may be linked to side effects from certain therapeutic medications. Acute hospital admissions for physical illnesses may therefore provide an opportunity for targeted suicide prevention among people with certain conditions, particularly alcohol related disorders.

Highlights

  • Suicide is a major public health issue with 800 000 deaths every year (World Health Organisation, 2017)

  • Increased suicide rates have been established for conditions including epilepsy (Hawton et al 1980; Bell et al 2009a, b; Singhal et al 2014; Erlangsen et al 2015), type I diabetes (Kyvik et al 1994; Singhal et al 2014; Erlangsen et al 2015), multiple sclerosis (Harris & Barraclough, 1994; Manouchehrinia et al 2016), cancers (Harris & Barraclough, 1994; Druss & Pincus, 2000; Crump et al 2014; Erlangsen et al 2015), and asthma (Crump et al 2014; Barker et al 2015), little has been reported for many other physical illnesses

  • The study was designed to investigate all possible physical illnesses that may be associated with substantial suicide mortality, with very little or nothing previously reported on possible links with suicide for many of these illnesses

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Summary

Introduction

Suicide is a major public health issue with 800 000 deaths every year (World Health Organisation, 2017). In the UK, there are approximately 6000 suicides annually, of which approximately 25% occur within 1 year of an acute hospital admission (Office for National Statistics, 2014; study data). The study aim was to establish and quantify suicide risk following acute admissions for all major physical illnesses, for confirmatory purposes, from two independent information sources from different countries

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