Abstract
Former findings indicate that suicidal behavior in bipolar disorder is associated with clock genes. Additionally, numerous non-genetic risk factors are potentially associated with suicidal behavior. Therefore, we conducted an analysis of the relationship between clock genes (as distal risk factors) with clinical characteristics and the course of bipolar disorder. We also tried to obtain a predictive model for suicide attempts based on clinical and genetic data.We found associations between selected polymorphisms and:–the number of depressive episodes (TIMELESS, PER3);–the average number of depressive episodes per year of illness (TIMELESS, ARNTL);–the ratio of depressive and hypo/manic episodes (TIMELESS);–the family history of suicidal attempt(s) (TIMELESS).
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