Abstract
Objective: Suicidal behavior in depressed patients is associated with low central serotonin. Thus, platelet serotonin uptake in relation to suicidal behavior in depression was examined. Methods: Depressed patients who had never attempted suicide (n = 23) were compared with depressed patients who had never attempted suicide (n = 26) and normal controls (n = 71) for platelet serotonin uptake. Results: Depressed patients who had a lifetime history of a suicide attempt had a significantly greater apparent Michaelis constant (K<sub>m</sub>) of platelet serotonin uptake than either depressed patients who had never attempted suicide or controls. Patients rated high for current suicidal ideation at the index admission had significantly higher K<sub>m</sub> values than patients rated low. Also, patients who reattempted or committed suicide during a 5-year follow-up period had significantly higher K<sub>m</sub> values than controls. Among women patients who had attempted suicide there was a significant correlation between extrapunitive hostility scores and K<sub>m</sub> values. Conclusion: The serotonin transporter warrants further study in relation to suicidal behavior in depression.
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