Abstract
Evidence suggestive of hepatotoxicity concomitant with the use of the antipsychotic tranquilizer thioridazine hydrochloride was seen in three cases. The first case with a history of increased serum glutamic oxaloacetic transaminase (SGOT) levels while taking chlorpromazine (Thorazine) responded to thioridazine with elevated values of alkaline phosphatase and serum glutamic pyruvic transaminase (SGPT). Clinical jaundice was noted. The second case with a history of parkinsonism and photosensitivity reaction on chlorpromazine presented with an increase in SGPT levels which progressively rose under continued administration of thioridazine. Concurrent pruritus, fatigue, and dark-colored urine accompanied the elevated transaminase levels. In the third case, SGPT and alkaline phosphatase values rose with thioridazine usage. Despite these findings, treatment with the medication (thioridazine) was maintained with a resultant return to normal values of the SGPT and alkaline phosphatase.
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