Abstract
XdT 12 and dT 5XdT 6, where X is 1-(4′-thio-β-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT 12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one.
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