SUFU reduced pancreatic cancer cell growth by Wnt/β-catenin signaling pathway

Duanmin Hu,Limin Liu

doi:10.1590/fst.61721

Abstract

The aim of the present study was to investigate the function and mechanism of SUFU in treatment of pancreatic cancer. Patient with pancreatic cancer (n = 50) and normal volunteers (n = 30) were obtained from The Second Affiliated Hospital of Soochow University between May 2014 and April 2013. SUFU mRNA and protein expressions in patients with pancreatic cancer were reduced as compared to normal saline. OS and DFS of high expression of SUFU in pancreatic cancer were higher than those of low expression of SUFU in pancreatic cancer. The inhibition of SUFU promoted pancreatic cancer cell growth and migration; SUFU reduced pancreatic cancer cell growth and migration. SUFU suppressed Wnt/β-catenin signaling pathway in pancreatic cancer cell lines. SUFU reduced pancreatic cancer cell growth by Wnt/β-catenin signaling pathway, providing a novel possibility for an understanding of pancreatic cancer pathogenesis.

Highlights

Pancreatic cancer is a highly malignant tumor of the digestive system, generally accompanied by acute complications and prone to metastasize (Gao et al, 2021)
suppressor of Fused (SUFU) protein expressions in patients with pancreatic cancer were reduced as compared to normal saline (Figure 1C, D)
To better understand the biological function of SUFU in pancreatic cancer cell lines, cell were transfected into CFPAC-1 with SUFU plasmids

Summary

Introduction

Pancreatic cancer is a highly malignant tumor of the digestive system, generally accompanied by acute complications and prone to metastasize (Gao et al, 2021). The median survival of patients with localized tumor and without metastasis is 6 to 10 months, which drops to 3-6 months in metastatic patients (Chu et al, 2017). The efficacy of radiochemotherapy is not ideal, causing potent toxic side effects (Chu et al, 2017). The efficacy of radiochemotherapy is not ideal, causing potent toxic side effects (Chu et al, 2017; Balthazar et al, 2021). The efficacy of immunotherapy and targeted therapy is not yet clear, which is difficult to prolong survival (Chu et al, 2017)

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