SU-E-T-550: Influence of the Clinical Outcome and Quality of Life by Replanning during Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinoma.

Abstract

The purposes of this study were to expound on the benefit of replanning using clinical outcome and Quality of life (QoL) during Intensity-Modulated Radiation Therapy (IMRT) for nasopharyngeal carcinoma (NPC). A total of 129 new patients with NPC, who were curatively treated by IMRT from June 2007 to August 2011, were recruited. Eighty-six patients with repeat CT and replanning and 43 patients non-replanning were retrospectively analyzed. The Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life (QoL) Questionnaire C30 and H&N were completed before treatment, the end of treatment, 1, 3, 6, 12 month after treatment. QoL and Kaplan- Meier estimators were used to estimate the survival function of patients with or without replanning. The clinical outcome comparison indicated that replanning during the IMRT for NPC improved the locoregional control (LRC) (p=0.040), but did not improved the overall survival (OS) (p=0.475). The 2-year LRC, OS rates were 92.4%, 82.2%, and 97.2%, 89.8% in non-replanning ans replanning, respectively. Global QoL (p=0.012) and role functioning (p=0.000) and social functioning (p=0.000) and dyspnea (p=0.001) and appetite loss (p=0.010) and constipation (p=0.010) and diarrhea (p=0.010) and speech problems (p=0.000) and trouble with social contact (p=0.000) and teeth (p=0.031) and opening mouth and dry mouth (p=0.000) and sticky saliva (p=0.015), have significantly differences between replanning and non-replanning in patients with NPC. Our results indicate that replanning can improve significantly LRC and QoL variables in patients with NPC. Grant No. 2008B198 from Zhejiang Provincial Medical and Health science Foundation of China.