Sudden onset of brown macules

Abstract

An eight-year-old boy develops multiple, small, brown macules over the dorsum of his feet and toes shortly after undergoing a successful kidney transplant and subsequent immunosuppression with azathioprine, prednisone, and cyclosporine (Fig 5). The macules persist and even darken slightly over a period of three years until his kidneys begin to fail and he is once again placed on hemodialysis. At this time, the lesions began to fade and several disappeared completely.6.What is the most likely diagnosis? (Choose the single best response.)a.Arthus reactionb.Chemotherapy induced hyperpigmentationc.Ephilidesd.Eruptive melanocytic nevie.Lentigo simplex7.This condition most likely develops from which of the following? (Choose the single best response.)a.Accumulation of antigen-antibody complexesb.Cutaneous manifestation of acute transplant rejectionc.Drug-induced hyperpigmentationd.Normal developmente.Transplant-associated immunosuppression8.The same condition has also been identified in which of the following? (Choose the single best response.)a.Acute lymphoblastic leukemiab.HIV/AIDSc.Immunosuppressive treatment of Crohn's diseased.Untreated adenocarcinomae.All of the above9.Melanomas in organ transplant patients are often histologically associated with (Choose the single best response.)a.Extensive regression at diagnosisb.Universal lack of pigmentc.Prominent lymphovascular invasiond.Precursor nevie.Vertical growth phase10.The most consistent dermoscopic feature of eruptive transplant-associated nevi is (Choose the single best response.)a.Blue-gray veilb.Hypopigmented areasc.Moth-eaten borderd.Peripheral rim of globulese.Reticulated pigment network