Abstract
Sudden hypocalcemia was induced in 10 normal subjects by infusion of 50 mg/kg of disodium EDTA over a 30- to 45-min interval. This resulted in a highly significant immediate reduction in the serum phosphorus concentration, followed by a significant rise in phosphorus clearance 3–6 hr after the infusion was stopped. The reduction in the serum phosphorus concentration may reflect a shift of phosphorus into the cells due to the hypocalcemia per se or to stimulation of the parathyroid glands secondary to the hypocalcemia. The delayed increase in phosphorus clearance may be due to a direct stimulation of the parathyroid glands secondary to the sudden reduction in serum calcium. Ten normal patients had no infusion of EDTA. Only 4 of the 10 showed an increase in phosphorus clearance. This suggests that the spontaneous early rise in phosphorus excretion is inconsistent in this group and subject to individual variation. The infusion of 50 mg/kg of calcium EDTA in another group of 10 normal subjects resulted in a r...
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