Abstract
Dr Mark Josephson and co-workers have collaborated with other well-known investigators to present comprehensive and current coverage of experimental and clinical aspects of sudden cardiac death. The book begins with discussion of pathological examples and ends with a chapter on common congenital lesions causing sudden death in infants, children, and adolescents. The bulk of the contribution is devoted to life-threatening arrhythmias in adult patients, with emphasis on coronary heart disease. The chronic canine myocardial ischemia model seems to have relevance to human sudden death. Enhanced sympathetic neural activity is closely related to the development of ventricular fibrillation during acute coronary occlusion. Thus, β-blockers can be helpful in controlling such fibrillation. Other data obtained in animals and man point to the role of platelets and prostaglandins in myocardial ischemia and electrical instability. Caution should be exercised in the use of antiarrhythmic drugs because of their tendency to aggravate arrhythmia. Electrophysiological testing
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