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Abstract
Inspired by biological systems, the development of artificial nanoscale materials that communicate over a short distance is still at its early stages. This work shows a new example of a cooperating system with intercommunicated devices at the nanoscale. The system is based on the new sucrose-responsive Janus gold-mesoporous silica (Janus Au-MS) nanoparticles network with two enzyme-powered nanodevices. These nanodevices involve two enzymatic processes based on invertase and glucose oxidase, which are anchored on the Au surfaces of different Janus Au-MS nanoparticles, and N-acetyl-L-cysteine and [Ru(bpy)3]2+ loaded as chemical messengers, respectively. Sucrose acts as the INPUT, triggering the sequential delivery of two different cargoes through the enzymatic control. Nanoscale communication using abiotic nanodevices is a developing potential research field and may prompt several applications in different disciplines, such as nanomedicine.
Highlights
Based on the cyclic regulation of the metabolic processes observed in biological reaction networks, we developed a communication system which consisted of three enzyme-controlled Janus Au-MS nanoparticles which displayed a double receiver-sender behavior [13,14]
The enzymes invertase and glucose oxidase (GOD) were anchored on the Au surface, and Nacetyl-L-cysteine and [Ru(bpy)3 ]2+ were loaded as cargoes into J1c and J2c, respectively
The local pH drop induced the opening of the pH-responsive β-cyclodextrin-based supramolecular nanovalve on the Mesoporous Silica Nanoparticles (MSNPs) face of J2c, and, the N-acetyl-L-cysteine was released
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Communication is the act of transmitting information. Every communication involves at least one sender, a message, and a recipient. It may seem simple, communication is a very complex process. Molecular communication, inspired by biological systems, uses molecules as an information medium
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