Abstract
28Jul 2016 SUCKLING-INDUCED BURST DISCHARGES OF SUPRAOPTIC OXYTOCIN NEURONS IN RATS: PROSTAGLANDIN MEDIATION OF OXYTOCIN ACTIONS Stephani C. Wang , Fengmin Zhang , Hui Zhu , Chunmei Lv , Xiaoyu Liu , Yu-Feng Wang , Danian Qin and Scott N. Currie. Department of Cell Biology & Neuroscience, University of California, Riverside, CA, USA. School of Basic Medical Sciences, Harbin Medical University, Harbin, China. Department of Physiology, Shantou University Medical College, Shantou, Guangdong. China.
Highlights
Patterned neural activity is widespread in mammalian neuroendocrine systems and appears to underlie pulsatile release of hormones and neurotransmitters in response to environmental challenges
The present study reveals that prostaglandin E2 (PGE2) can evoke burst-like firing in supraoptic oxytocin neurons that depends on PG production
The present study provides further evidence that PGs are essential signals in oxytocin receptors (OXTRs)-mediated burst discharges, and more direct triggers than pERK 1/2 in oxytocin neurons of the supraoptic nucleus (SON), since PGE2 evoked bursts had a higher incidence than oxytocin-evoked bursts did
Summary
Patterned neural activity is widespread in mammalian neuroendocrine systems and appears to underlie pulsatile release of hormones and neurotransmitters in response to environmental challenges. Our results support the hypothesis that PGs mediate suckling-elicited milk ejections by evoking burst discharges following activation of OXTRs in supraoptic oxytocin neurons.
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