Abstract
Effects of a set of α-ketoglutarate phosphoanalogues on the activity of α-ketoglutarate dehydrogenase (EC 1.2.4.2) complexes from E. coli and pigeon breast muscle, as well as on α-ketoglutarate dehydrogenase isolated from the pigeon breast muscle, have been studied. α-Ketoglutarate phosphoanalogues (succinyl phosphonate and its monomethyl ester) were found to be effective inhibitors of α-ketoglutarate oxidative decarboxylation, catalyzed by both muscle and bacterial α-ketoglutarate dehydrogenase complexes, as well as muscle α-ketoglutarate dehydrogenase. The ability of glutamate phosphoanalogues to inhibit α-ketoglutarate oxidative decarboxylation has been shown in E. coli extract and a model system.
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