Abstract
Background:In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods:A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p <0,01 is considered significant.Results:SDHB mutations are observed in 20 of 114 (17.54 %) PPGL cases, 3 (11,12%) of which is Pheo, 12 (16,44) is HNPGL, and 5 (35,71%) is TAPPGL (P <0,02). While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p <0,02), malignancy potential according to PASS classification (p <0,0001) and Ki-67 proliferation index (p <0,0001). Conclusion:To identify patients for molecular pathological examination, routine application of SDHB immunohistochemistry to PPGL tumors are suggested especially in HNPGLs.
Highlights
Paragangliomas and pheochromocytomas (PPGLs) are neuroendocrine tumors derived from the parasympathetic or sympathetic nervous system
While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification, 5/32 (15,63%) cases has (p=0,73)
thoraco-abdominal-pelvic paraganglioma (TAPPGL), head-neck paragangliomas (HNPGL) and Pheo sub-groups have a significant difference between SDHB expression (p
Summary
Paragangliomas and pheochromocytomas (PPGLs) are neuroendocrine tumors derived from the parasympathetic or sympathetic nervous system. PGLs arising from head and neck (HNPGL) are usually derived from parasympathetic paraganglia and are non-functional. Thoraco-abdominal-pelvic paragangliomas (TAPPGL) are usually derived from the sympathetic ganglia, as well as Pheo (McKenny, 2018; Donato et al, 2019). We aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p
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