Abstract
Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
Highlights
Intramedullary spinal cord tumours make up 3%–5% of pediatric cns tumours, with 70% being gliomas[1]
Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours
The prognosis for children with high-grade glioma remains poor despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy[2]
Summary
Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. We describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers
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