Abstract
Mild hepatic dysfunction in dengue haemorrhagic fever is not unusual. However, acute liver failure (ALF) is rare. When present, its management according to most current guidelines is supportive and carries a poor prognosis. We present a patient with dengue haemorrhagic fever complicated acute liver failure and hepatic encephalopathy who was successfully treated with N-Acetylcysteine (NAC) leading to complete recovery. DOI: http://dx.doi.org/10.4038/cmj.v57i4.5085 Ceylon Medical Journal 2012; 57 : 166-167
Highlights
Mild hepatic dysfunction in dengue haemorrhagic fever is not unusual
Treatment was initiated according to national dengue management guidelines [1]
The histopathological findings of fulminant hepatitis associated with dengue haemorrhagic fever is often characterised by hepatocellular necrosis, typically localising to zone 2 of the hepatic plate, a pauci-cellular inflammatory infiltrate and fatty changes
Summary
Mild hepatic dysfunction in dengue haemorrhagic fever is not unusual. Its management according to most current guidelines is supportive and carries a poor prognosis. We present a patient with dengue haemorrhagic fever complicated acute liver failure and hepatic encephalopathy who was successfully treated with N-Acetylcysteine (NAC) leading to complete recovery
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