Abstract
Childhood urticaria is not rare, although its persistence is less frequent. In children, chronic spontaneous urticaria (CSU) is associated with comorbidities, including asthma, allergic rhinitis, or atopic dermatitis, and many children with CSU have a family history of atopy. The therapeutic approach to CSU in children is the same one recommended by international guidelines for treatment of chronic urticaria in adults. In the European Union, according to the European Medicine Agency, omalizumab is the add-on drug of choice for the management of CSU in adult and adolescent patients (from 12 years of age) with inadequate response to H1 antihistamine therapy. In addition, in children (6 to <12 years of age), it is the add-on therapy of choice to improve asthma control. The management of children with urticaria under 12 is a therapeutic area with few certainties, where omalizumab can be administered only “off-label.”
Highlights
Chronic urticaria (CU) is a common skin disorder, characterized by the appearance of pruritic wheals or angioedema, persisting for longer than 6 weeks
We report the case of an 8-year-old child with severe asthma sensitized to Dermatophagoides pteronyssinus and D. farinae
The diagnosis of chronic spontaneous urticaria (CSU) is based on EAACI/GA2LEN/ EDF/WAO guidelines, and the evaluation of the clinical efficacy of omalizumab during therapy has been monitored with the Urticaria Activity Score (UAS 7) [2], which, before treatment, was 35
Summary
Chronic urticaria (CU) is a common skin disorder, characterized by the appearance of pruritic wheals or angioedema (and—in about 40% of cases—both manifestations), persisting for longer than 6 weeks. Asthma is the most common chronic lung disease in pediatric patients, and in 2–5% of cases, it remains symptomatic, despite the implementation of addressing modifiable risk factors and an adequate therapy (highdose inhaled corticosteroids, long-acting β2-receptor agonists, leukotriene receptor antagonists, and occasionally, systemic steroids) [7].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
