Successful Treatment, with Chemotherapy and Intravenous Administration of Ascorbic Acid, of a Patient with Peripheral T-Cell Lymphoma, Not Otherwise Specified

Abstract

Here, we report the case of a 64-year-old man with peripheral T-cell lymphoma, not otherwise specified, who complained of diffuse lymphadenopathy and pancytopenia. This patient received the CHOP regimen followed by the CHP plus brentuximab vedotin regimen, and eventually experienced severe adverse effects, such as leukocytopenia and thrombocytopenia. He was then intravenously administered high doses of ascorbic acid to enhance the effects of chemotherapy drugs and reduce the intensity of the side effects. Positron emission tomography-computed tomography revealed a complete response of the lesions to combination therapy. This case report demonstrated the feasibility, efficacy, and acceptable toxicity of high-dose ascorbic acid in patients undergoing chemotherapy.