Abstract
A 58-year-old woman presented with a history of subacute cutaneous lupus erythematosus (SCLE) for the past 6 years, associated with photosensitivity, arthralgia, and fatigue. There was no evidence of systemic lupus erythematosus (SLE) or any history of exposure to drugs known to induce SCLE. Previous treatments included hydroxychloroquine sulfate, dapsone, prednisone, azathioprine, mycophenolate mofetil, topical corticosteroids, and tacrolimus 0.1% ointment, with limited benefit. Examination of the skin revealed erythematous and variably hyperkeratotic plaques (Figure, A) covering 70% of the body surface area. Laboratory test results were positive for SS-A/Ro and antinuclear antibodies (titer 1:640) but negative for SS-B/La and double-stranded DNA antibodies. Histopathologic analysis demonstrated vacuolar interface dermatitis, with a superficial and middermal perivascular and periadnexal inflammatory infiltrate consisting of mononuclear cells. There were faint deposits of mucin. Direct immunofluorescence revealed focal cytoid bodies and IgG and fibrin deposits at the dermoepidermal junction. This constellation of findings was consistent with the diagnosis of SCLE. THERAPEUTIC CHALLENGE
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
