Abstract
Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis. Traditional disease modifying anti-rheumatic drugs (DMARDs) have shown inconsistent and unsatisfactory results. Treatment with biological agents has shown different results. Despite the evident efficacy of biologic agents for psoriasis and psoriatic arthritis, there is an increase in psoriasis following biologic agents’ therapies. Psoriasis has no permanent cure and represents a lifelong burden for affected patients. We report herein a successful therapeutic approach for PsA with widespread psoriasis using double filtration plasmapheresis (DFPP) in a 25-year-old female patient. Two months after the first DFPP treatment, a remarkable normalization of the clinical appearance was achieved. During the 3 years follow-up, the patient has had no detectable disease, and a sustained clinical remission has been maintained for 2 years after the interruption of therapy. DFPP therapy led to the complete regression of the severe disease. Therefore, we consider the therapy as promising for treatment of PsA.
Highlights
Psoriatic arthritis (PsA) is progressive, erosive, and destructive, resulting in marked impairment of the activities of daily living and poor quality of life
Despite the evident efficacy of biologic agents for psoriatic arthritis [2,3] and psoriasis [4], there is an increase in psoriasis following biologic agents therapies [5,6,7,8]
We report the first case of a successful treatment of PsA with widespread psoriasis using double filtration plasmapheresis (DFPP), its major mode of action is rapid depletion of specific diseaseassociated plasma factors [9]
Summary
PsA is progressive, erosive, and destructive, resulting in marked impairment of the activities of daily living and poor quality of life. Patients with PsA are usually affected with psoriasis before signs of joint disease have developed. Not life-threatening, psoriasis substantially affects health-related quality of life and has negative psychological and social implications. We report the first case of a successful treatment of PsA with widespread psoriasis using DFPP, its major mode of action is rapid depletion of specific diseaseassociated plasma factors [9].
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