Successful Treatment of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome with Shinbuto*

Yuichirou Tsuji,Chitose Karasawa

doi:10.4236/ijcm.2014.520160

Abstract

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30; Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.

Highlights

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children
PFAPA syndrome is characterized by periodic episodes of high fever lasting several days and recurring regularly every 1 to 3 months; the fever is often associated with aphthous stomatitis, pharyngitis, and adenitis
We prescribed shinbuto to a 10-years-old boy with PFAPA syndrome and were able to reduce the duration of his symptoms

Summary

Introduction

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. PFAPA was first reported by Marshall et al, 1987 in 12 pediatric patients [1]. PFAPA syndrome is characterized by periodic episodes of high fever lasting several days and recurring regularly every 1 to 3 months; the fever is often associated with aphthous stomatitis, pharyngitis, and adenitis. (2014) Successful Treatment of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome with Shinbuto. Karasawa etiology of PFAPA syndrome is still unknown. The treatment of this syndrome has not yet been established but some treatments have been reported. We report here the case of a male with PFAPA syndrome who had responded to treatment with shinbuto

Case Report

Discussion