Abstract
We report a case of Serratia marcescens meningitis that was unresponsive to therapy with ticarcillin plus systemic and intrathecal amikacin. The administration of moxalactam, 12 g/day intravenously, for 4 weeks resulted in eradication of the infection without sequelae. We were able to document therapeutic levels of moxalactam in the cerebrospinal fluid (CSF), and adequate CSF bactericidal activity was obtained. Moxalactam and other third generation cephalosporins may be valuable agents in the management of gram-negative bacillary meningitis. (Neurosurgery 10:762-765, 1982)
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