Abstract
Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. Now 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia.
Highlights
Fanconi anemia (FA) is associated with an increased risk of malignancy, and patients with FA are extremely sensitive to the toxics effects of chemotherapy [1,2,3,4,5]
We report the clinical case of FA with T-cell acute lymphoblastic leukemia (ALL), severe vincristine neuropathy, and disseminated aspergillosis with a successful outcome after modified chemotherapy and allogeneic bone marrow transplant
Reduced dose of intrathecal methotrexate
Summary
Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia
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