Abstract
"Successful Treatment of Extranodal Natural Killer T Cell Lymphoma Nasal Type Complicated by Severe Hemophagocytic Syndrome A Case Report"
Highlights
Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type(ENKL), is a rare malignancy of Non-Hodgkin lymphoma characterized by an aggressive clinical course and poor prognosis [1]
Han et al conducted a study comparing natural killer (NK)/T-LymphomaAssociated Hemophagocytic Syndrome (LAHS) with LAHS associated with other T cell lymphomas, which indicated that both had poor prognosis with a median survival time of 28 and 33 days, respectively [10]
There is no recommended treatment for ENKL complicated with Hemophagocytic Syndrome (HPS) because of the extreme rarity of this entity
Summary
Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type(ENKL), is a rare malignancy of Non-Hodgkin lymphoma characterized by an aggressive clinical course and poor prognosis [1]. About ten days later he presented to a local hospital with the above-mentioned chief complaint and a chest computed tomography scan showed multiple nodules, ground-glass opacities and patchy infiltration scattered in both lung fields He had been treated as for pneumonia. We performed a ultrasound-guided percutaneous puncture biopsy of soft tissue at the lower margin of the right 9th rib Immunohistochemical staining of these two specimens both yielded positive results for CD56, CD3, CD2,and the Ki-67 proliferation index was 80%;in situ hybridization for EBV-encoded early small RNAs (EBER) was positive; results were negative for CD79a,CD20. The patient chose a different hospital to continue the treatment He achieved CR(complete remission) confirmed by using positron emission tomography-computed tomography (PETCT)with the therapy of anti-PD1 antibody(Tislelizumab Injection) and Chidamide.
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