Successful Treatment of Cryptococcus albidus Keratitis with Voriconazole 1% Drops and Oral Itraconazole

Abstract

The Cryptococcus genus, include a wide group of yeast, which species are usually found in water and plants. C neoformans and C gatti are considered pathogens for humans and animals, whoever Cryptococcus laurentii, C albidus and C curvatus are considered as potential environmental pathogen for both. We describe one fungal keratitis caused by Cryptococcus albidus, in a male 41 years old, diagnosed previously with diabetes type 2, and ocular surgery for cataract extraction 7 years before, actually he presented a corneal ulcer in right eye diagnosed before as herpetic keratitis unresponsive to Aciclovir, after de first ocular observation in our hospital in Cornea Service, and samples for culture taken, the final diagnosis was Cryptococcus albidus keratitis, the treatment with antimycotic drugs, topic voriconazole 1% and oral itraconazole 100mgs each 12 hs was administered. The corneal ulcer was healed in 3 weeks and the FBCVA was 20/30.