Successful Treatment of Bing-Neel Syndrome Using Intrathecal Chemotherapy and Systemic Combination Chemotherapy Followed by BEAM Auto-Transplant: A Case Report and Review of Literature

Abstract

Neurological complications occur in approximately 25% ofpatients with WM. Although they are most often present as pe-ripheral neuropathy, hyperviscosity can produce central nervoussystem (CNS) changes that resolve promptly after plasma exchange.Rarely is the CNS directly involved as is the case in Bing-Neelsyndrome (BNS), which results from infiltration of pons, medulla,periventricular white matter, or leptomeningeal spaces by lympho-plasmacytoid cells.