Successful transseptal puncture and cryoballoon ablation of symptomatic paroxysmal atrial fibrillation via jugular access in a patient with bilateral thrombotic femoral vein occlusion

Abstract

Key Teaching Points•The use of a steerable sheath with a long transseptal needle is a safe and effective alternative for transseptal puncture once superior access has been determined.•The cryoballoon technique can be considered as an alternative to pulmonary vein isolation due to the right jugular vein approach.•Because of the high amount of fluoroscopy time, special attention should be paid to proper radiation protection. •The use of a steerable sheath with a long transseptal needle is a safe and effective alternative for transseptal puncture once superior access has been determined.•The cryoballoon technique can be considered as an alternative to pulmonary vein isolation due to the right jugular vein approach.•Because of the high amount of fluoroscopy time, special attention should be paid to proper radiation protection. Pulmonary vein isolation (PVI) is the cornerstone of interventional treatment for atrial fibrillation. Radiofrequency (RF) ablation using 3-dimensional navigation systems, as well as cryoballoon ablation, are the recommended ablation techniques under the current guidelines.1Kirchhof P. Benussi S. Kotecha D. et al.2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.Europace. 2016; 18: 1609-1678Crossref PubMed Scopus (1432) Google Scholar Cryoballoon ablation has become the preferred technique in many institutions as the first-line ablation approach because it leads to significantly fewer repeat ablations, direct-current cardioversions, all-cause rehospitalizations, and cardiovascular rehospitalizations during follow-up.2Kuck K.H. Fürnkranz A. Chun K.R. et al.FIRE AND ICE InvestigatorsCryoballoon or radiofrequency ablation for symptomatic paroxysmal atrial fibrillation: reintervention, rehospitalization, and quality-of-life outcomes in the FIRE AND ICE trial.Eur Heart J. 2016; 37: 2858-2865Crossref PubMed Scopus (220) Google Scholar PVI is usually performed via common femoral vein access. However, there are a few situations where the inferior approach is not feasible—for example, the interruption of the inferior vena cava (IVC) with continuation of the azygos vein draining the blood from the IVC to the upper part of the right atrium via the superior vena cava.3Koc Z. Oguzkurt L. Interruption or congenital stenosis of the inferior vena cava: prevalence, imaging, and clinical findings.Eur J Radiol. 2007; 62: 257-266Abstract Full Text Full Text PDF PubMed Scopus (109) Google Scholar Transseptal puncture (TP) and the isolation of pulmonary veins (PV) via the internal jugular vein has been described as feasible but challenging, requiring several modifications of standard equipment.4Lim H.E. Pak H.N. Tse H.F. Lau C.P. Hwang C. Kim Y.H. Catheter ablation of atrial fibrillation via superior approach in patients with interruption of the inferior vena cava.Heart Rhythm. 2009; 6: 174-179Abstract Full Text Full Text PDF PubMed Scopus (51) Google Scholar, 5Kato H. Kubota S. Yamada Y. et al.Circumferential pulmonary vein ablation of atrial fibrillation via superior vena cava approach in a patient with interruption of the inferior vena cava.Europace. 2010; 12: 746-748Crossref PubMed Scopus (19) Google Scholar, 6Kato H. Kubota S. Goto T. et al.Transseptal puncture and catheter ablation via the superior vena cava approach for persistent atrial fibrillation in a patient with polysplenia syndrome and interruption of the inferior vena cava: contact force–guided pulmonary vein isolation.Europace. 2017; 19: 1227-1232PubMed Google Scholar, 7Baszko A. Kałmucki P. Dankowski R. Łanocha M. Siminiak T. Szyszka A. Transseptal puncture from the jugular vein and balloon cryoablation for atrial fibrillation in a patient with azygos continuation of an interrupted inferior vena cava.Europace. 2015; 17: 1153-1156Crossref PubMed Scopus (13) Google Scholar Here we report cryoballoon ablation of the PV via the superior approach using a steerable sheath and standard equipment in a patient with symptomatic paroxysmal atrial fibrillation and bilateral thrombotic occlusion of the common femoral veins after intravenous drug abuse. A 35-year-old male patient was referred to our institution with symptomatic (EHRA IV) atrial fibrillation. The patient, whose antiarrhythmic therapy with beta-blockers failed, was also flecainide intolerant. The patient also presented with bilateral occlusion of the common femoral vein after bilateral deep vein thrombosis owing to intravenous drug abuse. This was documented by means of duplex ultrasound and computed tomography angiography. The patient signed the written informed consent for this special case. For the assessment of the anatomy of the PV, magnetic resonance imaging was performed before the procedure. Four PV separately draining to the left atrium (LA) were presented. The PV anatomy was considered optimal for cryoballoon ablation. The procedure was performed under general anesthesia using propofol and midazolam. A steerable decapolar diagnostic catheter (Inquiry, 5F, Abbott, Chicago, IL) was inserted into the coronary sinus via cannulation using right internal jugular vein access with a short 6F sheath. Additional access to the right internal jugular vein was obtained using a second short 6F sheath, which was replaced by an 8.5F steerable sheath (Agilis NXT Steerable Indroducer, 71 cm, large curve, Abbott) with a long transseptal needle (BRK1-XS, 98 cm, Abbott). The TP was successfully performed under fluoroscopy, transesophageal echocardiographic guidance, and continuous pressure monitoring, without any difficulty. The sheath was then inserted into the IVC position. After curving and pulling of the sheath, the tip of the sheath reached the desired segment of the atrial septum. Tenting of the intraatrial septum was verified via transesophageal echocardiography (Video 1). The sheath was then pushed forward slightly so the curve of the sheath lay down toward the tricuspid valve annulus and allowed better support and high puncture. Once the proper position was reached, the long transseptal needle was inserted carefully into the introducer. After the puncture was done, the needle was removed and a 0.32-inch, 260-cm wire was inserted and positioned in the left inferior pulmonary vein (LIPV), followed by placement of the tip of the Agilis sheath into the LIPV ostium. The steerable decapolar catheter was then moved from the coronary sinus into the right ventricular apex. Angiography of the LA was performed during rapid right ventricular apex pacing (300 ms), using a 50 mL syringe for the manual contrast injection. The technique was modified from the angiography method published previously.8Imnadze G. Kranig W. Grove R. Wolff E. Thale J. The ABC of a Simple Method for Pulmonary Vein Angiography.Indian Pacing Electrophysiol J. 2014; 14: 53-59Crossref PubMed Scopus (3) Google Scholar The 8.5F steerable sheath was exchanged for the 12F steerable cryoballoon sheath (FlexCath, Medtronic, Quebec, Canada) (Figures 1 and 2).Figure 2A: The diagnostic catheter placed in the right ventricle for the rapid pacing (S1 300 ms). The angiography was performed manually using the 50 mL syringe with the pure contrast medium. B: Schematic illustration of the left atrium and the ostia of the pulmonary veins in this case. LIPV = left inferior pulmonary vein; LSPV = left superior pulmonary vein; RIPV = right inferior pulmonary vein; RSPV = right superior pulmonary vein.View Large Image Figure ViewerDownload Hi-res image Download (PPT) A 28-mm Arctic Front Advance cryoballoon was inserted. The FlexCath enabled cannulation of all PV. For the “real-time” monitoring of PV potentials, the Achieve circular mapping catheter (Medtronic) was inserted via the inner lumen of the cryoballoon catheter. The angiographic and schematic illustration of the cryoballoon position during the application in all pulmonary veins is presented in Figure 3. The characteristics of the cryo applications are presented in Table 1.Table 1Characteristics of cryo applicationsPVDegree of occlusionMinimal temperature (°C)Total freezing time (seconds)Time to isolation (seconds)∗Because of the deep position of the Achieve catheter, the time to isolation was not registered in LSPV and RIPV.Number of aborted applicationsLIPV3−41240703LSPV3/4/4−44/−48/−48300/180/180-1RSPV4−482401102RIPV3−44300-1LIPV = left inferior pulmonary vein; LSPV = left superior pulmonary vein; PV = pulmonary vein; RIPV = right inferior pulmonary vein; RSPV = right superior pulmonary vein.Degrees of occlusion were defined as follows: 4 = full occlusion; 3 = with the small lack of contrast.∗ Because of the deep position of the Achieve catheter, the time to isolation was not registered in LSPV and RIPV. Open table in a new tab LIPV = left inferior pulmonary vein; LSPV = left superior pulmonary vein; PV = pulmonary vein; RIPV = right inferior pulmonary vein; RSPV = right superior pulmonary vein. Degrees of occlusion were defined as follows: 4 = full occlusion; 3 = with the small lack of contrast. After 30 minutes of waiting time, an exit and entry block of all PV was presented. Total ablation time came to 180 minutes. Total fluoroscopy time was 72.5 minutes and the air kerma dose was 713 mGy. The sheaths were removed after the procedure without reversing the heparin with protamine. After hemostasis was obtained (a Z-suture was used), the patient was transferred to the intensive cardiac unit. The patient was discharged from the hospital on day 4. During the 12-month follow-up, the patient did not experience any episodes of palpitation. Repeated 12-lead electrocardiograms and Holter electrocardiograms did not register any episodes of atrial fibrillation. The bilateral occlusion of the common femoral vein after bilateral deep vein thrombosis in the present case was presumably due to the patient’s drug abuse. Administering drugs into a deep vein—usually in the groin—results in such vascular complications as thrombophlebitis and thrombosis with further occlusion.9Mackenzie A. Laing R. Douglas J. Greaves M. Smith C. High prevalence of iliofemoral venous thrombosis with severe groin infection among injecting drug users in North East Scotland: successful use of low molecular weight heparin with antibiotics.Postgrad Med J. 2000; 76: 561-565Crossref PubMed Scopus (62) Google Scholar There is a 13.9% prevalence of previous deep vein thrombosis in users of opioids, with an annual incidence rate of 3.2% reported recently.10Cornford C.S. Mason J.M. Inns F. Deep vein thromboses in users of opioid drugs: incidence, prevalence, and risk factors.Br J Gen Pract. 2011; 61: e781-786Crossref PubMed Scopus (37) Google Scholar In previously published cases using the RF ablation technique for atrial fibrillation ablation via superior access, together with jugular vein, the subclavian vein was cannulated. The TP was done using an SL3 sheath in these cases. However, in the first case using cryoballoon, TP was produced with an SL0 sheath.4Lim H.E. Pak H.N. Tse H.F. Lau C.P. Hwang C. Kim Y.H. Catheter ablation of atrial fibrillation via superior approach in patients with interruption of the inferior vena cava.Heart Rhythm. 2009; 6: 174-179Abstract Full Text Full Text PDF PubMed Scopus (51) Google Scholar, 5Kato H. Kubota S. Yamada Y. et al.Circumferential pulmonary vein ablation of atrial fibrillation via superior vena cava approach in a patient with interruption of the inferior vena cava.Europace. 2010; 12: 746-748Crossref PubMed Scopus (19) Google Scholar, 6Kato H. Kubota S. Goto T. et al.Transseptal puncture and catheter ablation via the superior vena cava approach for persistent atrial fibrillation in a patient with polysplenia syndrome and interruption of the inferior vena cava: contact force–guided pulmonary vein isolation.Europace. 2017; 19: 1227-1232PubMed Google Scholar, 7Baszko A. Kałmucki P. Dankowski R. Łanocha M. Siminiak T. Szyszka A. Transseptal puncture from the jugular vein and balloon cryoablation for atrial fibrillation in a patient with azygos continuation of an interrupted inferior vena cava.Europace. 2015; 17: 1153-1156Crossref PubMed Scopus (13) Google Scholar It should be mentioned that systems specifically designed for superior TP for left ventricular pacing are currently available.11Morgan J.M. Biffi M. Gellér L. et al.ALSYNC InvestigatorsALternate Site Cardiac ResYNChronization (ALSYNC): a prospective and multicentre study of left ventricular endocardial pacing for cardiac resynchronization therapy.Eur Heart J. 2016; 37: 2118-2127Crossref PubMed Scopus (107) Google Scholar In our case, we used a double puncture of the right jugular vein without any complications at the access site. The Z-suture was successfully used for hemostasis. The TP was performed under fluoroscopy, transesophageal echocardiographic guidance, and continuous pressure monitoring using the 8.5F steerable sheath and a long transseptal needle. Using this technique, we were able to deflect the sheath to the desirable place and insert the intraatrial septum at a maximally higher level. Another important aspect of the success in this case was the position of the operator. As described in the first case series, compared with the femoral venous approach, catheter manipulation (clockwise and counterclockwise rotations) via the superior approach is reversed.4Lim H.E. Pak H.N. Tse H.F. Lau C.P. Hwang C. Kim Y.H. Catheter ablation of atrial fibrillation via superior approach in patients with interruption of the inferior vena cava.Heart Rhythm. 2009; 6: 174-179Abstract Full Text Full Text PDF PubMed Scopus (51) Google Scholar Moreover, in our case we have also identified the importance of the proper position for the operator. After the operator moved to the head side of the patient, the maneuvering of the balloon catheter became similar to a femoral approach. However, the operator should keep in mind that the head-side position is associated with the highest exposure during the intervention, and maximal attention should be paid to radiation protection. Although a contact leak below the balloon exists during femoral access, the “pulling down” technique is recommended.12Chun K.R. Schmidt B. Metzner A. et al.The ‘single big cryoballoon’ technique for acute pulmonary vein isolation in patients with paroxysmal atrial fibrillation: a prospective observational single centre study.Eur Heart J. 2009; 30: 699-709Crossref PubMed Scopus (301) Google Scholar In the present case, as in the first report using the cryoballoon, the reverse “pulling up” technique was required to achieve LIPV isolation (Video 2). Baszko and colleagues7Baszko A. Kałmucki P. Dankowski R. Łanocha M. Siminiak T. Szyszka A. Transseptal puncture from the jugular vein and balloon cryoablation for atrial fibrillation in a patient with azygos continuation of an interrupted inferior vena cava.Europace. 2015; 17: 1153-1156Crossref PubMed Scopus (13) Google Scholar reported a total procedural time and fluoroscopy time using the cryoballoon of 210 minutes and 78 minutes, respectively. In our case, the procedure time was 180 minutes with a fluoroscopy time of 72.5 minutes. In our opinion, this was owing to a lack of experience and the limited number of case reports. The RF ablation and 3-dimensional navigation systems are used in most cases (5 cases described in the literature), but the duration of the procedure and radiation levels were not stated in those reports.4Lim H.E. Pak H.N. Tse H.F. Lau C.P. Hwang C. Kim Y.H. Catheter ablation of atrial fibrillation via superior approach in patients with interruption of the inferior vena cava.Heart Rhythm. 2009; 6: 174-179Abstract Full Text Full Text PDF PubMed Scopus (51) Google Scholar, 5Kato H. Kubota S. Yamada Y. et al.Circumferential pulmonary vein ablation of atrial fibrillation via superior vena cava approach in a patient with interruption of the inferior vena cava.Europace. 2010; 12: 746-748Crossref PubMed Scopus (19) Google Scholar, 6Kato H. Kubota S. Goto T. et al.Transseptal puncture and catheter ablation via the superior vena cava approach for persistent atrial fibrillation in a patient with polysplenia syndrome and interruption of the inferior vena cava: contact force–guided pulmonary vein isolation.Europace. 2017; 19: 1227-1232PubMed Google Scholar This was one of the reasons why we leaned toward the cryoballon technique. Moreover, in recent years, experience with PVI using the cryoballoon has grown extensively in our institution. The fluoroscopy time in our case was a bit shorter than reported previously but is still high, and we hope it can be decreased gradually through increased experience and detailed reports of such cases. It should be noted that retrograde access of the left atrium for PVI using a magnetic navigation system (if available at the clinic) is a feasible and safe alternative in patients for whom the classic transseptal approach is impossible.13De Roeck L. Riahi L. Wijchers S. Stockman D. De Greef Y. Schwagten B. Retrograde access of the left atrium for pulmonary vein isolation using magnetic navigation after closure of an atrial septum defect.Neth Heart J. 2015; 23: 368-369Crossref PubMed Scopus (5) Google Scholar Fortunately we did not face any complications in our case, but with regard to this kind of intervention, the operator should keep in mind that in patients who have undergone cryoballoon ablation, the incidence of iatrogenic atrial septal defect is frequent in comparison to the RF ablation technique14Naksuk N. Asirvatham S.J. Iatrogenic atrial septal defect: reassurance or inquisitiveness.J Interv Card Electrophysiol. 2018; 52: 137-140Crossref PubMed Scopus (7) Google Scholar and potentially could be even more so because of superior access. This is the second successful case of PVI using the cryoballoon owing to the right jugular vein approach. The steerable sheath with the use of a long transseptal needle is a safe and effective alternative to TP using superior access.