Abstract
Background.Graft-size disparity negatively impacts the postoperative outcome in the setting of adult-to-adult living donor liver transplantation. Materials and methods.As a model for partial liver transplantation in rats using a minimized graft volume, we orthotopically transplanted a 20% reduced-size liver with the two-cuff method. Blood chemistry, graft weight restoration, and labeling indices of 5-bromo-2′-deoxyuridine were estimated. Results.We achieved 100% 2-week survival. Hepatic mass was restored rapidly with early normalization of biochemical parameters, although albumin synthesis capacity required more time to recover. Conclusions.This technique has great potential for research as well as a therapeutic approach to regeneration and functional recovery of small liver grafts under various posttransplant circumstances.
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