Abstract
BackgroundIn this report, we describe the first successful case of transition from subcutaneous administration of treprostinil to selexipag in a patient with severe pulmonary arterial hypertension (PAH), by evaluating hemodynamic changes and exercise tolerance.Case presentationA 38-year-old female with idiopathic PAH (IPAH) had received initial triple combination therapy (macitentan PO, tadalafil PO, and treprostinil SC) and achieved excellent improvement in hemodynamics. Afterwards, due to the development of side effects from subcutaneous administration, we replaced treprostinil therapy with oral selexipag, resulting in stable hemodynamic parameters and exercise capacities.ConclusionsWe report the first case of successful replacement of treprostinil (20.1 ng/kg/min) with selexipag (1600 μg BID) as a component of triple combination therapy, which provides incentive to perform a larger, prospective exchange study.
Highlights
In this report, we describe the first successful case of transition from subcutaneous administration of treprostinil to selexipag in a patient with severe pulmonary arterial hypertension (PAH), by evaluating hemodynamic changes and exercise tolerance.Case presentation: A 38-year-old female with idiopathic PAH (IPAH) had received initial triple combination therapy and achieved excellent improvement in hemodynamics
Recent reports have supported the benefits of triple combination therapy, including the use of prostacyclin, in patients with severe pulmonary arterial hypertension (PAH) [1]
We describe the first successful case of transition from subcutaneous administration of treprostinil to oral selexipag in a patient with severe PAH, as assessed by evaluating hemodynamic changes and exercise tolerance
Summary
We report the first case of successful replacement of treprostinil (20.1 ng/kg/min) with selexipag (1600 μg BID) as a component of triple combination therapy, which provides incentive to perform a larger, prospective exchange study.
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