Abstract

Isolated levocardia with situs inversus is an extremely rare type of situs anomaly with an estimated incidence of 1 per 22,000 in the general population. This autosomal recessive situs anomaly has been described as normal levo position of the heart with dextro position of the abdominal viscera. In this case report, we describe accidental diagnosis of isolated levocardia with situs inversus in pediatric patient while evaluating for heart murmur. Systematic examination of the patient identified the presence of patent ductus arteriosus, anomalous course of inferior vena cava and bovine aortic arch. We shared our experience of successful transcatheter closure of patent ductus arteriosus. This case report is worth reporting both, for demonstrating the possibility of the percutaneous device closure of the patent ductus arteriosus in patient with this unusual situs anomaly to interventional cardiologists and because of scanty of literature.

Highlights

  • The term “Situs” is used to define position of asymmetric organs of the human body relative to the midline

  • If the heart is in the normal position but the abdominal viscera are transposed laterally, it is known as isolated levocardia with Situs inversus (SI) [4]

  • Recent research has shown that mutations in the genes which are involved in the determination of the left-right asymmetry, for example lefty, nodal, inversus viscerum (iv), HAND, ZIC3, sonic hedgehog (Shh), ACVR2B and Pitxz, are implicated in situs anomalies [11]

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Summary

Introduction

The term “Situs” is used to define position of asymmetric organs of the human body relative to the midline. (2016) Successful Transcatheter Closure of Patent Ductus Arteriosus in Isolated Levocardia with Situs Inversus. The published data suggest higher prevalence of congenital cardiac anomalies in patients with isolated levocardia with SI. This situs anomaly is usually identified at birth or soon afterwards if associated congenital cardiac anomalies are severe and complex [7] [8]. To the best of our knowledge, this is the first case-report which demonstrated successful transcatheter closure of PDA in pediatric patient with situs anomaly. The combination of presence of bovine aortic arch, anomalous course of inferior vena cava (IVC) and PDA in patient with isolated levocardia with SI has not been reported so far in the literature

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