Abstract
New Candida species may cause bloodstream infections challenging current therapeutic approaches because of unpredictable susceptibility and virulence. In the present report, we describe a fungemia case due to Candida pulcherrima in a premature neonate. After full in vitro diagnostic workup, the neonate was successfully treated with liposomal amphotericin B and micafungin achieving rapid fungal eradication from blood.
Highlights
Candida species are the third most frequently isolated pathogens from blood cultures in neonatal late-onset sepsis (9–13%) [1]
Candida albicans has been historically the most frequent pathogen in neonates followed by Candida parapsilosis and other Candida species such as Candida tropicalis, Candida glabrata and Candida krusei [3,4]
In the present case report, we describe a rare case of fungemia by Candida pulcherrima in a premature neonate together with the diagnostic and therapeutic approaches followed
Summary
Candida species are the third most frequently isolated pathogens from blood cultures in neonatal late-onset sepsis (9–13%) [1]. On day 0 he developed symptoms and sign of sepsis with fever to 38°C, paleness, indolence and acrocyanosis His laboratory results demonstrated thrombocytopenia (min 21,000/mm3) and increased CRP (max 51 mg/L). Four days after initiation of liposomal amphotericin B, the blood cultures remained positive for the same yeast and micafungin 10 mg/kg/d i.v. was added on day 7. His general condition was improved progressively, CRP levels decreased (o3 mg/L) and after two days of combined antifungal therapy on day 9 the blood cultures became negative. On day 30, the neonate was discharged from the hospital in good condition and with normal laboratory results
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