Successful suspension-based viral vector manufacturing scale-up from process development to clinic

Abstract

Cell and gene therapies have emerged as promising treatments for previously untreatable diseases, with viral vectors being used as the current preferred delivery vehicle. Safe, robust, and cost-effective vector manufacturing processes are necessary to support the demands of the patient population. Here, expert therapy developers, solutions providers, and CDMOs discuss considerations for the successful scale-up of viral vector processes from bench to commercial manufacturing.