Successful Surgical Treatment of Refractory Status Epilepticus in a 12-Day-Old Infant

Abstract

Medically refractory epilepsy adds to significant morbidity in the infant population and increases the risk for future neurocognitive dysfunction. Epilepsy surgery should be considered an option in young infants who have catastrophic, localizable epilepsy despite the implementation of optimal first-line therapies. 1 Kumar R.M. Koh S. Knupp K. Handler M.H. O’Neill B.R. Surgery for infants with catastrophic epilepsy: an analysis of complications and efficacy. Childs Nerv Syst. 2015; 31: 1479-1491 Crossref PubMed Scopus (31) Google Scholar , 2 Gowda S. Salazar F. Bingaman W.E. et al. Surgery for catastrophic epilepsy in infants 6 months of age and younger. J Neurosurg Pediatr. 2010; 5: 603-607 Crossref PubMed Scopus (47) Google Scholar There is limited literature focusing on epilepsy surgery in young infants, and more reports and multicenter studies are needed. 1 Kumar R.M. Koh S. Knupp K. Handler M.H. O’Neill B.R. Surgery for infants with catastrophic epilepsy: an analysis of complications and efficacy. Childs Nerv Syst. 2015; 31: 1479-1491 Crossref PubMed Scopus (31) Google Scholar , 2 Gowda S. Salazar F. Bingaman W.E. et al. Surgery for catastrophic epilepsy in infants 6 months of age and younger. J Neurosurg Pediatr. 2010; 5: 603-607 Crossref PubMed Scopus (47) Google Scholar , 3 Gonzalez-Martinez J.A. Gupta A. Kotagal P. et al. Hemispherectomy for catastrophic epilepsy in infants. Epilepsia. 2005; 46: 1518-1525 Crossref PubMed Scopus (124) Google Scholar , 4 Oluigbo C. Pearl M.S. Tsuchida T.N. Chag T. Ho C.Y. Gaillard W.D. Endovascular embolic hemispherectomy: a strategy for the initial management of catastrophic holohemispheric epilepsy in the neonate. Childs Nerv Syst. 2017; 33: 521-527 Google Scholar , 5 Duchowny M. Jayakar P. Resnick T. et al. Epilepsy surgery in the first three years of life. Epilepsia. 1998; 39: 737-743 Crossref PubMed Scopus (217) Google Scholar This is the youngest reported patient to undergo successful epilepsy surgery with seizure-free and favorable neurological outcome.