Successful reduction of hospital-acquired methicillin-resistant Staphylococcus aureus in a urology ward: a 10-year study.

Manabu Tatokoro,Minato Yokoyama,Toshiki Kijima,Fumitaka Koga,Kazunori Kihara,Hitoshi Masuda,Soichiro Yoshida,Masaya Ito,Yasuhisa Fujii,Satoru Kawakami,Kazutaka Saito

doi:10.1186/1471-2490-13-35

Manabu Tatokoro, Minato Yokoyama + Show 9 more

Open Access

https://doi.org/10.1186/1471-2490-13-35

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Journal: BMC urology	Publication Date: Jul 18, 2013
Citations: 31	License type: cc-by

Affiliation: Tokyo Medical and Dental University

Abstract

BackgroundTo eradicate hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) using a stepwise infection control strategy that includes an avoidance of antimicrobial prophylaxis (AMP) based on surgical wound classification and an improvement in operative procedures in gasless single-port urologic surgery.MethodsThe study was conducted at an 801-bed university hospital. Since 2001, in the urology ward, we have introduced the stepwise infection control strategy. In 2007, surveillance cultures for MRSA in all urological patients were commenced. The annual incidence of MRSA was calculated as a total number of newly identified MRSA cases per 1,000 patient days. Trend analysis was performed using a Poisson regression.ResultsOver the study period, 139,866 patients, including 10,201 urology patients, were admitted to our hospital. Of these patients, 3,719 patients, including 134 ones in the urology ward, were diagnosed with MRSA throughout the entire hospital. Although the incidence of MRSA increased throughout the entire hospital (p = 0.002), it decreased significantly in the urology ward (p < 0.0001). Of the 134 cases, 45 (33.6%) were classified as “imported,” and 89 (66.4%) as “acquired.” In the urology ward, the incidence of acquired MRSA decreased significantly over time (p < 0.0001), whereas the incidence of imported MRSA did not change over time (p = 0.66). A significant decrease (p < 0.0001) in the incidence of clinically significant MRSA infection over time was found.ConclusionsStepwise infection control strategy that includes a reduction or avoidance of antimicrobial prophylaxis in minimally invasive surgery can contribute to a reduction in hospital-acquired MRSA.Trial registrationCurrent study has approved by the institutional ethical review board (No.1141).

Highlights

To eradicate hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) using a stepwise infection control strategy that includes an avoidance of antimicrobial prophylaxis (AMP) based on surgical wound classification and an improvement in operative procedures in gasless single-port urologic surgery
Over the study period, 139,866 patients, including 10,201 urology patients, were admitted to Tokyo Medical and Dental University (TMDU) Hospital. For both the entire hospital and the urology ward, the mean duration of hospital stay decreased by approximately 40% (Figure 2A), the annual number of hospital admissions doubled (Figure 2B) and the annual number of surgeries increased by approximately 50% (Figure 2C) over time
The incidence of MRSA increased throughout the entire hospital, it decreased significantly in the urology ward (Figure 3A)

Summary

Introduction

To eradicate hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) using a stepwise infection control strategy that includes an avoidance of antimicrobial prophylaxis (AMP) based on surgical wound classification and an improvement in operative procedures in gasless single-port urologic surgery. We have already reported that AMP can be gradually reduced or avoided in gasless single-port urologic surgery [9,10] without increasing the risk of SSI [11,12,13,14].

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