Successful pregnancy and its outcome in a woman with 46XX gonadal dysgenesis

Abstract

A 25-year-old lady with 3 years of primary infertility was diagnosed with an infantile uterus, premature ovarian failure due to streak gonads, and 46XX gonadal dysgenesis. She has received hormone therapy irregularly since menarche and gets withdrawal bleeding only after taking estrogen and progesterone combination. She also received three cycles of ovulation induction elsewhere. Her transvaginal ultrasonogram (USG) showed uterus that measured 4.1 × 2.3 cms, right ovary measured 1.4 × 0.9 × 1.08 cm and left ovary could not be visualized. She was given hormone replacement therapy to achieve optimal uterine size for a period of 1 year and achieved pregnancy with the second cycle of the donor oocyte program. She developed early onset-gestational hypertension and underwent elective lower segment caesarean section (LSCS) at 37 weeks. At cesarean section, fallopian tubes were normal and ovaries were small in size and streak like. An alive female baby was delivered who weighed 3.5 kg.