Successful pregnancy and delivery after testicular sperm extraction despite an undetectable concentration of serum inhibin B in a patient with nonobstructive azoospermia

Abstract

Objective: To describe a successful pregnancy and delivery after testicular sperm extraction (TESE) despite an undetectable concentration of serum inhibin B in a man with nonobstructive azoospermia. Design: Case report. Setting: Obstetrics and gynecology and reproductive biology departments. Patient(s): A 31-year-old woman and a 32-year-old man with nonobstructive azoospermia and an undetectable inhibin B serum level. Intervention(s): TESE, testicular spermatozoa cryopreservation, intracytoplasmic sperm injection (ICSI). Main Outcome Measure(s): Pregnancy and delivery. Result(s): Successful pregnancy and delivery of a normal healthy child following a third ICSI cycle with frozen-thawed spermatozoa extracted from the testis. Conclusion(s): This case report shows that there is no minimal level of inhibin B below which TESE is always unsuccessful. The delivery of a normal healthy baby is strong evidence to perform TESE in these circumstances.