Abstract
BackgroundGastric cancer rarely metastasizes to the oral cavity, especially to gingiva. Only 18 cases have been reported worldwide to date. This paper herein presents the nineteenth case of gingival metastasis from gastric cancer.Case presentationA 75-year-old man who underwent a radical gastrectomy for gastric adenocarcinoma was admitted to clinical oncology center for gingival mass which was originally diagnosed as epulis. The subsequent positron emission tomography-computed tomography (PET-CT) and histopathological examination revealed a gingival metastatic adenocarcinoma originated from gastric carcinoma. Then three-dimensional conformal radiotherapy (3D–CRT) with synchronization and sequential chemotherapy demonstrated clinical benefit in this patient. Furthermore, this research reviewed the records of 18 cases of gingival metastasis from gastric carcinoma in English, Japanese, and Chinese literature, and summarized the clinicopathologic features of the disease based on previously published papers.ConclusionThis case suggests that gingival metastasis from gastric cancer is worthy of vigilance. Biopsy and immunohistochemical (IHC) staining should be used for the final diagnosis. Moreover, the patient with uncommon gingival metastatic lesion can be successfully treated by radiotherapy with adjuvant chemotherapy.
Highlights
Gastric cancer rarely metastasizes to the oral cavity, especially to gingiva
This paper reported a male patient who presented with a gingival lump that was determined to be a metastasis from a primary gastric adenocarcinoma and found that the combination of radiochemotherapy led to improved clinical benefit
Case presentation A 75-year-old Chinese male, who was diagnosed with gastric adenocarcinoma and who underwent a radical total gastrectomy, was admitted to the clinical oncology center on 27 June 2016 due to the presence of an indolent lump on his gingiva
Summary
This case suggests that gingival metastasis from gastric cancer is worthy of vigilance. The patient with uncommon gingival metastatic lesion can be successfully treated by radiotherapy with adjuvant chemotherapy
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