Abstract
Purpose: To describe a second case of viability past the first trimester despite an inappropriate rise of the serum human chorionic gonadotropin (hCG) levels in the early pregnancy. Materials and Methods: A serum beta hCG level was obtained 17, 28, and 31 days after conception. Serial sonographic studies were performed throughout the first trimester and into the early second trimester. Results: The first serum hCG level at 17 days from conception was appropriate at 484 mIU/mL. The serum beta hCG level did not appropriately increase at 28 and 31 days (4, 844 and 9, 585 mIU/mL), respectively. Nevertheless fetal viability was seen on sonography throughout the first and early second trimesters She delivered a full-term healthy baby. Also for the first time a full-term delivery of a healthy baby from the first described case is reported (this case had only described surviving the first trimester. Conclusions: A delivery of a healthy baby despite inappropriate rising serial beta hCG levels is possible but rare.
Highlights
Miscarriages occur in 20% or more of pregnancies demonstrating fetal heart activity by ultrasonography [1, 2], It has been well documented that dropping, slow rising, or low levels of serum beta human chorionic gonadotropin are associated with miscarriage [3, 4]
The aforementioned studies refer to multiple serum samples showing inappropriate rise of serum human chorionic gonadotropin (hCG)
One case was found who successfully completed the first trimester despite an inappropriate rise in the hCG levels [6]
Summary
Summary Purpose: To describe a second case of viability past the first trimester despite an inappropriate rise of the serum human chorionic gonadotropin (hCG) levels in the early pregnancy. Materials and Methods: A serum beta hCG level was obtained 17, 28, and 31 days after conception. Results: The first serum hCG level at 17 days from conception was appropriate at 484 mIU/mL. The serum beta hCG level did not appropriately increase at 28 and 31 days (4,844 and 9,585 mIU/mL), respectively. Fetal viability was seen on sonography throughout the first and early second trimester.s She delivered a full-term healthy baby. For the first time a full-term delivery of a healthy baby from the first described case is reported Conclusions: A delivery of a healthy baby despite inappropriate rising serial beta hCG levels is possible but rare
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