Abstract
SLET TRANSPLANTATION is considered to be the most theoretical option for insulin-dependent diabetes mellitus (IDDM). The islet graft survival is, however, still limited because of the difficulty of avoiding an acute rejection, despite of the use of immunosuppressant. To improve the results of clinical islet transplantation, a new approach to realize the complete inhibition of rejection should be developed. Gene transfection technique into the islets may become the new approach of immunosuppression and induction of the immunoacceptance. Retrovirus and adenovirus vector-mediated gene transfer technique, however, may not be suitable for clinical islet transplantation according to ethical view. Thus, in this study we examined the utility of the liposome-mediated gene transfer technique into murine pancreatic islets.
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