Abstract
METHYLXANTHINES (aminophylline, theophylline, and caffeine) have been demonstrated to be effective in the therapy of respiratory insufficiency resulting from apnea of prematurity). 2 Theophylline has been shown to improve lung compliance and to reduce expiratory resistance in infants during the early phase of evolving bronchopulmonary dysplasia. 3 In these infants with bronchopulmonary dysplasia, four of five patients younger than 1 month were successfully weaned to endotracheal continuous end expiratory pressure within 72 hours of theophylline administration? To date, there have been no controlled studies to evaluate the use of aminophylline for extubating infants with respiratory distress syndrome from mechanical venti
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